Nixxi Health News

Researchers Learn to Predict Very Preterm Birth, Neonatal Complications in Early Pregnancy

From Indiana University School of Medicine INDIANAPOLIS—Researchers are learning more about ways to predict the likelihood of newborn complications from early in pregnancy using samples provided by the Indiana University School of Medicine Building Blocks of Pregnancy Biobank. Preterm birth is a common pregnancy complication that can lead to significant neonatal morbidity and mortality. Very preterm birth, which is delivery before 32 weeks gestation, is particularly associated with increased rates of complications in newborns. In a new study published in PLOS ONE, researchers looked at levels of progesterone metabolites as well as the demographic and obstetric history of patients. They found that by looking at the combination of these factors, they could accurately predict how likely a pregnant woman was to deliver very preterm or have a newborn with multiple complications. Pregnancies predicted to be at-risk in the study resulted in newborns spending about seven weeks longer in the neonatal intensive care unit (NICU) than those at lower risk. “These discoveries about different progesterone metabolites and their roles in prediction and potentially prevention of spontaneous preterm birth are very exciting,” said David Haas, MD, MS, vice chair of research for IU School of Medicine Department of Obstetrics and Gynecology and a co-author of the paper. “While more research is needed, these findings are a significant step in helping physicians provide multidisciplinary, personalized care to improve perinatal outcomes for their patients.” The study, led by Avinash Patil, MD,...

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Nixxi Launches the First Widely Available Digital Health Screening Tool for Preterm Birth

Nixxi’s PopNatal™ offers the earliest and most cost-effective identification of women at risk for premature delivery. PHOENIX (PRWEB) NOVEMBER 16, 2020 Nixxi, a women’s health company with a mission to improve pregnancies and pregnancy outcomes, announces the launch of PopNatal, a proprietary digital assessment of a woman’s risk for premature delivery. The current standard of care, which largely consists of history-based screening, misses 93% of women who will have a premature delivery. Based on advanced technology developed by leading maternal-fetal medicine physicians and data scientists, PopNatal identifies nearly ten times more women at risk for preterm birth than current screening methods in early pregnancy. Early identification provides health care providers and women with the best opportunities to take proactive steps to reduce preterm birth risk. PopNatal is a clinical decision support tool that provides actionable intelligence to health care providers for patient management. PopNatal is immediately available to women, clinicians, and healthcare payors. How it Works A woman who is planning for a pregnancy, or upon learning she is pregnant, may register on the Nixxi website (https://nixxihealth.com) for access to PopNatal. She will be asked to provide information about herself and her health history within the secure and HIPAA-compliant portal. Nixxi then analyzes hundreds of data points using a proprietary algorithm in order to produce a risk assessment. Within 72 hours, Nixxi reports the results to the woman’s health care provider. The results allow the woman and...

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Nixxi Developing Mass Spec Test Targeting Preterm Birth Space

We are pleased to share 360dx's profile of Nixxi. Our company is focused on creating clinical tools that address the most critical segment of premature births - those delivered prior to 32 weeks. Additionally, as reported, we are exploring solutions from another perspective - the ability to accurately predict neonatal outcomes early in pregnancy.Apr 30, 2020 | Adam Bonislawski NEW YORK – Start-up Nixxi is developing a mass spectrometry-based test for identifying mothers at high risk of delivering prematurely. In April, researchers affiliated with the Phoenix, Arizona-based firm published a study in Human Reproduction Open that found that maternal serum levels of 11-deoxycorticosterone (DOC) and 16-alphahydroxyprogesterone (16α-OHP) could be used to predict an increased risk delivery prior to 32 weeks. The company is now in the middle of a second study validating those results, said Avi Patil, Nixxi's founder and CEO. Additionally, the company is looking to expand its research to look directly at factors predictive of neonatal outcomes, he said. Preterm birth is a relatively common issue in the US. According to numbers from the March of Dimes, around 1 in 10 babies are born prematurely with costs to the healthcare system totaling more than $25 billion per year. While interventions like vaginal progesterone or increased surveillance of cervical shortening can be used to improve management of women at risk of preterm delivery, tools for assessing women's risk levels have traditionally been lacking. One of the major predictors of preterm delivery is having previously given...

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Alterations in Endogenous Progesterone Metabolism Associated with Spontaneous Very Preterm Delivery

A peer-reviewed study from Nixxi, just published in Human Reproduction Open, demonstrates that measurement of two different steroid hormones in the blood of women early in pregnancy may be predictive for an increased risk for delivery prior to 32 weeks, which is classified as a very preterm delivery. Very preterm deliveries are associated with higher rates of complications, greater likelihood of long-term care needs, and greater costs to the healthcare system. The study is publicly accessible at: https://academic.oup.com/hropen/article/2020/2/hoaa007/5816056 Preterm birth is common and is an important source of long-term handicaps and mortality for newborns. Currently, there are limited tools available to identify which pregnant women will deliver prematurely. Identification of women at risk for preterm delivery is important to facilitate targeted treatment or enhanced care to decrease the likelihood of having a premature baby. Reviewing a woman’s obstetric history is the primary means by which providers have to screen an individual woman for risk of preterm delivery, as a prior spontaneous preterm delivery is an important risk factor. Despite this, the vast majority of preterm deliveries occur in women without a history of preterm birth. Spontaneous preterm birth is increasingly being recognized to represent a common end pathway for a number of different disease phenotypes that include infection, inflammation, premature rupture of the membranes, uterine over distension, cervical insufficiency, placental dysfunction and genetic predisposition. In addition to these...

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